Abstract
OBJECTIVE:
This study was undertaken to describe a new prenatal diagnosis program among human immunodeficiency virus (HIV)-infected women, and the perinatal outcome of this program’s application over a more than 2-year period.
STUDY DESIGN:
From June 2000 to December 2003, all HIV-infected women who were booked into the antenatal clinic before 20 weeks were offered a screening for chromosomal anomalies, with midtrimester amniocentesis in the tests that were positive.
RESULTS:
A total of 116 pregnancies (including 3 sets of twins) were seen: 96 women were offered and accepted screening for chromosomal anomalies. Thirteen pregnancies had a positive screening test and amniocentesis was performed in 10 at median 16.5 gestational weeks: a trisomy 21 and a monosomy X were diagnosed. No vertical transmissions were documented by age 6 months in the 6 liveborn infants who underwent amniocentesis.
CONCLUSION:
A program of prenatal diagnosis for chromosomal anomalies appears to be effective when applied to HIV-infected women, although safety remains to be proven.
Year: 2006
Journal: American Journal of Obstetric and Gynecology
PMID: 16389031
Centers: Congratulations to Aina Nicolau for defending her Master’s Thesis New publication in Molecular Human Reproduction New publication in the Journal of Assisted Reproduction and Genetics Agustina Alessandroni has joined our laboratory to pursue her PhD degree.